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Preventing infection, facilitating healing: New biomaterials from spider silk

Subhanshu Singh by Subhanshu Singh
अगस्त 30, 2020
in infection, Preventing
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New biomaterials developed at the University of Bayreuth may eliminate the risk of infection and facilitate healing processes. A research team led by Prof. Dr. Thomas Scheibel has succeeded in combining these material properties which are highly relevant to biomedicine. These nanostructured materials are based on spider silk proteins. They prevent colonization by bacteria and fungi, but at the same time proactively assist in the regeneration of human tissue. They are therefore ideal for implants, wound dressings, prostheses, contact lenses, and other everyday aids. The scientists have presented their innovation in the journal Materials Today.

It is a widely underestimated risk of infection: Microbes settling on the surfaces of objects indispensable in medical therapy or for quality of life generally. Gradually, they form a dense, often invisible biofilm that cannot be easily removed, even by cleaning agents, and which often is resistant against antibiotics and antimycotics. Bacteria and fungi can then migrate into the adjacent tissue of the organism. As a result, they not only interfere with various processes of healing, but can even cause life-threatening infections.

With a novel research approach, University of Bayreuth scientists have now found a solution to this problem. Using biotechnologically produced spider silk proteins, they have developed a material that prevents the adhesion of pathogenic microbes. Even streptococci, resistant to multiple antibacterial agents (MRSA), have no chance of settling on the material surface. Biofilms growing on medical instruments, sports equipment, contact lenses, prostheses, and other everyday objects may therefore soon be history.

Moreover, the materials are designed to simultaneously aid the adhesion and proliferation of human cells on their surface. If they can be used for e.g. wound dressings, skin replacement, or implants, they proactively support the regeneration of damaged or lost tissue. In contrast to other materials that have previously been used to regenerate tissue, the risk of infection is intrinsically eliminated. Microbial-resistant coatings for a variety of biomedical and technical applications are thus set to become available in the near future.

The Bayreuth researchers have so far successfully tested the microbe-repellent function on two types of spider silk materials: on films and coatings that are only a few nanometres thick and on three-dimensional hydrogel scaffolds which can serve as precursors for tissue regeneration. “Our investigations to date have led to a finding that is absolutely ground-breaking for future research work. In particular, the microbe-repellent properties of the biomaterials we have developed are not based on toxic, i.e. not cell-destroying, effects. The decisive factor rather lies in structures at the nanometre level, which make the spider silk surfaces microbe-repellent. They make it impossible for pathogens to attach themselves to these surfaces,” explains Prof. Dr. Thomas Scheibel, who is the Chair of Biomaterials at the University of Bayreuth.

“Another fascinating aspect is that nature has once again proven to be the ideal role model for highly advanced material concepts. Natural spider silk is highly resistant to microbial infestation and the reproduction of these properties in a biotechnological way is a break-through,” adds Prof. Dr.-Ing. Gregor Lang, one of the two first authors and head of the research group of Biopolymer Processing at the University of Bayreuth.

In the Bayreuth laboratories, spider silk proteins were specifically designed with various nanostructures in order to optimize biomedically relevant properties for specific applications. Once again, the networked research facilities on the Bayreuth campus have proven their worth. Together with the Bavarian Polymer Institute (BPI), three other interdisciplinary research institutes of the University of Bayreuth were involved in this research breakthrough: the Bayreuth Centre for Material Science & Engineering (BayMAT), the Bayreuth Centre for Colloids & Interfaces (BZKG), and the Bayreuth Centre for Molecular Biosciences (BZKG).

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Materials provided by Universität Bayreuth. Note: Content may be edited for style and length.

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  • graphic neural network
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  • gravitational wave
  • Gravity
  • gravity waves
  • green drone
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  • growth
  • guidance
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  • Guilt
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  • hacking
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  • Handgrip
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  • happier
  • haptics
  • hard truths
  • harder
  • hardware
  • harvard
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  • have your cake and eat it too
  • hawc
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  • health
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  • heat wave
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  • Heavy
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  • hell to the no
  • hellfeed
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  • Helminth
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  • henry zaga
  • hepa
  • Here's
  • herman cain
  • heroes
  • hey email app
  • higher
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  • hillary clinton
  • hints
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  • hitting the books
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  • holiday
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  • home
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  • home schooling
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  • homepage
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  • honeybees
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  • honor
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  • Hostgator
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  • Hotspots'
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  • hp deals
  • htc
  • Huawei
  • Hubble
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  • hugo weaving
  • human
  • Hunter
  • hunters
  • hurricane katrina
  • hurricane laura
  • hurricane season
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  • hypersonic
  • hypersonic missiles
  • hypertension
  • hyperx
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  • i miss midi music
  • ian alexander
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  • ice ice maybe
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  • India
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  • indoor
  • inexpensive
  • Infants
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  • Inflammation
  • influencer
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  • Informing
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  • infotainment
  • Ingenious
  • initiation
  • injunction
  • Inkjet
  • Insect
  • Insight
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  • insta360
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  • Instagram
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  • interventions
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  • invest
  • Investigational
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  • Islanders
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  • JBL's
  • jeans
  • jedi
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  • jetpacks
  • jim butcher
  • JioFiber
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  • journalism
  • juicer
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  • Jumping'
  • jumpstarts
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  • just transition
  • Justice
  • juul
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  • kamala harris
  • Karaoke
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  • Keeping
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  • lab-grown
  • Labor
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  • laika
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  • lana wachowski
  • landlords
  • laptop
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  • large attachments
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  • latest
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  • lawsuit
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  • layout
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  • League
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  • leak
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  • Linux
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  • mach 5
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  • magicbook pro 16
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  • mail
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  • Mail's
  • maintain
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  • makes
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  • malaria
  • males
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  • Mandalorian
  • Mandalorian's
  • mandy patinkin
  • manipulated media
  • map
  • mapping
  • marijuana
  • marine
  • Mario
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  • mario kart live
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  • mark zuckerberg
  • market
  • Marketing
  • martial arts
  • marvel
  • marvel cinematic universe
  • marvel comics
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  • masks
  • massive entertainment
  • massiveentertainment
  • mastodon
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  • mate 40
  • MatePad
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  • Matric
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  • matter
  • matterport
  • mattress
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  • mauritius
  • max-q
  • meat
  • mechanical
  • media
  • MediaTek
  • mediatonic
  • medicine
  • mega city one
  • mega-shark
  • meghan markle
  • meghanmarkle
  • meh deals
  • members
  • memes
  • memory
  • mental health
  • mentality
  • mergers and acquistions
  • messages
  • messenger
  • metadata
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  • Meteorite
  • method
  • metroid
  • miami
  • michael k williams
  • Microbes
  • microfiber
  • Microgel
  • Microsoft
  • microsoft edge
  • Microsoft's
  • mid-range
  • Middle
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  • midi controller
  • migrations
  • miir deals
  • military technology
  • militias
  • Millions
  • Minecraft–
  • Miniature
  • minimize
  • mining
  • mirrorless
  • mirrorless cameras
  • misha green
  • misinformation
  • mistakes
  • mite-y
  • mixed reality
  • mixes
  • mobil
  • mobile
  • mobile phones
  • Mobile's
  • mocks
  • model
  • model 3
  • model s
  • model x
  • model y
  • moderna
  • modification
  • mods
  • modular synthesizer
  • mojang
  • molecular
  • Molecule
  • monique candelaria
  • monitor
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  • months
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  • more oled laptops please
  • mortality
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  • motor vehicles
  • Motorola
  • motorola one
  • motorola one 5g
  • Motorola's
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  • moveaudio s200
  • movie
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  • movies
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  • mozilla firefox
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  • mr carey
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  • MSI's
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  • Munster
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  • music
  • music making
  • music quiz
  • musical instruments
  • Musk's
  • mustang
  • mustang mach-e
  • mutations
  • myneato
  • mystery
  • mystery jetpack
  • myths
  • naked
  • naming
  • Nanoearthquakes
  • nanomachine
  • nasa
  • national security agency
  • Nations
  • Natural
  • Nature
  • naughty dog
  • Neanderthals
  • neato
  • neato d10
  • neato d8
  • neato d9
  • nebraska
  • needles
  • needs
  • Neglected
  • nemesis
  • neon
  • nest
  • nest hello
  • netflix
  • networks
  • neuralink
  • neurons
  • new mutants
  • new orleans
  • new swift 5 and swift 3 from acer
  • new tab page
  • new years eve
  • newegg
  • newegg deals
  • newest
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  • news
  • newsletter
  • newyork
  • next-gen
  • nfl
  • nfl network
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  • ngo
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  • nick antosca
  • nickelodeon
  • nicolas cage
  • nike
  • nike deals
  • niki caro
  • nikola tesla
  • ninebot
  • ninja
  • nintendo
  • nintendo switch
  • nintendo switch deals
  • Nitro
  • no man's sky
  • no time to die
  • noah ringer
  • noise
  • noise cancelling
  • noise-canceling
  • Nokia
  • nokia 3310
  • Nominet
  • north korea
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  • nos4a2
  • nostalgia
  • not the fun jedi saga
  • notebook
  • notice
  • Novak
  • Novel
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  • nsa
  • nsa scandal
  • nubia watch
  • nubia watch review
  • Nuclear
  • Nuggets
  • nuke
  • Nurses
  • nvidai
  • nvidia
  • nvidia geforce
  • nvidia rtx 3070
  • nvidia rtx 3080
  • nvidia rtx 3090
  • Nvidia’s
  • nvidiageforce
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  • nyc
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  • Ocean
  • oceans
  • oculus quest
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  • official
  • oil and gas
  • oil spill
  • older
  • Olufsen's
  • olympics
  • on demand
  • oneplus
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  • oneplus watch
  • online
  • online dating application
  • OnlyFans
  • onmail
  • open the flood gates
  • opens
  • operating
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  • Operation
  • opioids
  • Oracle
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  • origami
  • origin
  • Orion
  • orion pictures
  • others
  • our garbage president
  • outage
  • outages
  • Outbreak
  • Overcast's
  • overheating
  • OVHcloud
  • oxygen
  • P-Series
  • p40 pro
  • pacemakers
  • packages
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  • paleontology
  • panasonic
  • panasonic lumix s5
  • Panasonic's
  • Pandemic
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  • patent
  • Pattinson
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  • paypal
  • pbug
  • pc
  • pc gaming
  • pc/ laptops
  • pco
  • peacock
  • Peculiar
  • peddling to nowhere
  • pedro pascal
  • peloton
  • penguin random house
  • pens
  • Pentagon
  • People
  • permafrost
  • permanent
  • permanently
  • permuted press
  • Personal
  • personal computing
  • personal data
  • personalization
  • petrochemicals
  • pfizer
  • Philips
  • philips hue
  • phone
  • phone cases
  • phone trees
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  • Photography
  • photon
  • Photos
  • pictures
  • pilot
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  • Pinterest
  • pinterest today
  • pique your interest
  • Pixel
  • plague rallies
  • planetary
  • planetary science
  • plans
  • Plant
  • plants
  • Plasmin
  • plastic
  • plastic pollution
  • platforms
  • play store
  • playstation
  • playstation 4
  • playstation 5
  • playstation vr
  • playstation4
  • playstationvr
  • please help my brain its very sick
  • please no
  • pleasure
  • plugin
  • poaching
  • poco x3
  • pocox3
  • podcast
  • podcasts
  • point-of-care
  • pokemon go
  • polar orbit
  • Polestar
  • polestar 2
  • police
  • police shootings
  • policy
  • Political
  • political ads
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  • Pollination
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  • porsche
  • Portable
  • portable speaker
  • portable speakers
  • portfolios
  • Portugal
  • possessor
  • Possible
  • Post-COVID
  • postal apocalypse
  • postal service
  • potential
  • powerful
  • powertrain
  • practical magic
  • pre-order
  • Predator
  • predator x25
  • predict
  • predictions
  • pregnancy
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  • Premiere
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  • president
  • president trump
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  • pressure cooker
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  • presumably
  • Preventing
  • preview
  • price
  • price drop
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  • primal
  • Prime
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  • prince harry
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  • principles
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  • Prior
  • prison phone app
  • privacy
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  • problems
  • processor
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  • Program
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  • project
  • project 10 million
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  • projector
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  • proof
  • Proposed
  • props
  • propulsion
  • prosthetics
  • protein
  • protests
  • prototype
  • provide
  • ps plus
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  • ps3
  • ps4
  • ps5
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  • pubg
  • pubg corporation
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  • qanon
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  • quadruple
  • Qualcomm
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  • qualcomm snapdragon 8cx gen 2
  • Qualcomm's
  • quantum
  • quarter mile
  • quicker
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  • quote
  • quote tweet
  • race
  • race car
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  • racism
  • Radiocarbon
  • Radiologists
  • Raised
  • ralph macchio
  • ram
  • rami ismail
  • RAMPOW
  • randomised
  • Raptors
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  • ray-tracing
  • raytheon
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  • razer
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  • razer deals
  • Razer's
  • razr
  • razr 2
  • reaches
  • readily
  • real estate
  • reality
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  • realtor
  • recent
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  • Redmi
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  • renewable energy
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  • Report
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  • Republican
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  • retweet with comment
  • reunite
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  • richard branson
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  • right
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  • Robert
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  • robot
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  • rosamund pike
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  • rough
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  • rtx
  • rtx 30 series
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  • rumor
  • rumors
  • running
  • rupert murdoch
  • rural
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  • s1
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  • samara weaving
  • samsung
  • samsung deals
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  • Samsung's
  • san francisco
  • sandragon 8cx
  • Santana
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  • satechi
  • satellite
  • satellites
  • saucy nugs
  • savings
  • scam
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  • scanwatch
  • school
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  • sci fi
  • science
  • Scientist
  • scientists
  • scorched
  • score
  • scott pruitt
  • scream 5
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  • sd-03
  • Seagate
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  • season
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  • sedan
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  • segway
  • segway es2
  • select
  • self driving car
  • self-centered
  • self-driving
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  • sells
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  • Sennheiser
  • sensing
  • sensor
  • September
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  • Serena
  • Serengeti
  • Series
  • series 3
  • services
  • Severe
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  • Shadowlands
  • shares
  • sharing
  • shenmue
  • shenmue 3
  • shield
  • shopping
  • short-throw projector
  • shortcut
  • shortcuts
  • shows
  • shudder
  • shut up and take my money
  • siberia
  • sick days
  • side deal deals
  • sidedeals
  • sights
  • signs
  • Silicon
  • Silver
  • simply
  • simulating
  • simulation
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  • sinkholes
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  • skyscraper
  • slack
  • sleep
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  • smart clock
  • smart glasses
  • smart home
  • smart homes
  • smart lighting
  • smart lights
  • smart lock
  • smart speakers
  • smarthome
  • smartlighting
  • smartlock
  • smartphone
  • smartphones
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  • smartwatches
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  • smoker
  • smoking
  • snapdragon
  • snapdragon 732g
  • snapdragon 765
  • snapdragon 8cx
  • snapdragon 8cx gen 2
  • social
  • social distancing
  • social life
  • social media
  • social media mistakes
  • social network
  • social networking
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  • software
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  • solo pro
  • solve
  • Songbirds
  • Sonos
  • sony
  • Sony's
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  • south korea
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  • space
  • space race
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  • SpaceX
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  • speakers
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  • star trek 4
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  • star trek the motion pictureinside the art and visual effects
  • star wars
  • star wars galaxys edge
  • star wars rebels
  • star wars the high republic
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